Non-coding RNAs in cardiac autophagy following myocardial infarction

Archive ouverte

Turkieh, Annie | Charrier, Henri | Dubois-Deruy, Emilie | Porouchani, Sina | Bouvet, Marion | Pinet, Florence

Edité par CCSD ; Hindawi -

International audience. Macroautophagy is an evolutionarily conserved process of the lysosome-dependent degradation of damaged proteins and organelles and plays an important role in cellular homeostasis. Macroautophagy is upregulated after myocardial infarction (MI) and seems to be detrimental during reperfusion and protective during left ventricle remodeling. Identify new regulators of cardiac autophagy may help to maintain the activity of this process and protect the heart from MI effects. Recently, it was shown that non-coding RNAs (microRNAs and long non-coding RNAs) are involved on autophagy regulation in different cell types including cardiac cells. In this review, we summarized the role of macroautophagy in the heart following MI and we focused on the non-coding RNAs and their targeted genes reported to regulate autophagy in the heart under these pathological conditions.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion