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Cellular and viral Fos proteins are degraded by different proteolytic systems

Archive ouverte | Acquaviva, C. | CCSD

International audience. c-Fos proto-oncoprotein is a short-lived transcription factor degraded by the proteasome in vivo. Its mutated forms expressed by the mouse osteosarcomatogenic retroviruses, FBJ-MSV and FBR-MS...

Degradation of cellular and viral Fos proteins

Archive ouverte | Acquaviva, C. | CCSD

International audience

Identification of a C-terminal tripeptide motif involved in the control of rapid proteasomal degradation of c-Fos proto-oncoprotein during the G(0)-to-S phase transition

Archive ouverte | Acquaviva, C. | CCSD

International audience. c-Fos proto-oncoprotein is rapidly and transiently expressed in cells undergoing the G(0)-to-S phase transition in response to stimulation for growth by serum. Under these conditions, the rap...

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