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Enhanced triacylglycerol production in the diatom Phaeodactylum tricornutum by inactivation of a Hotdog-fold thioesterase gene using TALEN-based targeted mutagenesis

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Hu, Xiahui | Hu, Ling | Jouhet, Juliette | Rébeillé, Fabrice | Maréchal, Eric | Hu, Hanhua | Pan, Yufang | Tan, Xiaoming | Chen, Zhuo | You, Lingjie | Chen, Hong | Wei, Fang | Gong, Yangmin

Edité par CCSD ; BioMed Central -

International audience. In photosynthetic oleaginous microalgae, acyl-CoA molecules are used as substrates for the biosynthesis of membrane glycerolipids, triacylglycerol (TAG) and other acylated molecules. Acyl-CoA can also be directed to beta-oxidative catabolism. They can be utilized by a number of lipid metabolic enzymes including endogenous thioesterases, which catalyze their hydrolysis to release free fatty acids. Acyl-CoA availability thus plays fundamental roles in determining the quantity and composition of membrane lipids and storage lipids.

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