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H19 antisense RNA can up-regulate igf2 transcription by activation of a novel promoter in mouse myoblasts

Archive ouverte | Tran, V. G. | CCSD

International audience. It was recently shown that a long non-coding RNA (lncRNA), that we named the 91H RNA (i.e. antisense H19 transcript), is overexpressed in human breast tumours and contributes in trans to the ...

EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos

Archive ouverte | Auclair, G. | CCSD

International audience. The extent to which histone modifying enzymes contribute to DNA methylation in mammals remains unclear. Previous studies suggested a link between the lysine methyltransferase EHMT2 (also know...

Targets and dynamics of promoter DNA methylation during early mouse development

Archive ouverte | Borgel, J. | CCSD

International audience. DNA methylation is extensively reprogrammed during the early phases of mammalian development, yet genomic targets of this process are largely unknown. We optimized methylated DNA immunoprecip...

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