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The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells

Archive ouverte | Sabater, Laurent | CCSD

International audience

Towards the Development of Photo-Reactive Ruthenium (II) Complexes Targeting Telomeric G- Quadruplex DNA

Archive ouverte | Weynand, Justin | CCSD

International audience. The design and characterization of new ruthenium(II) complexes aimed at targeting G-quadruplex DNA is herein reported. Importantly, they are based on oxidizing 1,4,5,8-tetraazaphenanthrene (T...

iMab antibody binds single-stranded cytosine-rich sequences and unfolds DNA i-motifs

Archive ouverte | Boissieras, Joseph | CCSD

International audience. Abstract i-Motifs (iMs) are non-canonical, four-stranded secondary structures formed by stacking of hemi-protonated CH+·C base pairs in cytosine-rich DNA sequences, predominantly at pH < 7...

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