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Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation

Archive ouverte | Niedner-Boblenz, Annika | CCSD

Abstract RNA-binding proteins are essential for gene regulation and the spatial organization of cells. Here, we report that the yeast ribosome biogenesis factor Loc1p is an intrinsically disordered RNA-binding protein with eight r...

Segmental, domain-selective perdeuteration and small angle neutron scattering for structural analysis of multi-domain proteins.

Archive ouverte | Sonntag, Miriam | CCSD

International audience. Multi-domain proteins play critical roles in fine-tuning essential processes in cellular signaling and gene regulation. Typically, multiple globular domains that are connected by flexible lin...

1H, 13C and 15N backbone chemical shift assignments of SARS-CoV-2 nsp3a

Archive ouverte | Salvi, Nicola | CCSD

International audience. The non-structural protein nsp3 from SARS-CoV-2 plays an essential role in the viral replication transcription complex. Nsp3a constitutes the N-terminal domain of nsp3, comprising a ubiquitin...

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