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Hippocampal synaptic reorganizations and functional recovery following entorhinal lesions : APOE4 modulation of the cholinergic sprouting and the glutamatergic reinnervation. Réorganisations synaptiques dans l'hippocampe et récupération fonctionnelle après lésion du cortex entorhinal : effets de l'allèle APOE4, du bourgeonnement cholinergique et de la réinnervation glutamatergique

Archive ouverte | Bott, Jean-Bastien | CCSD

Mild Cognitive Impairments (MCI) often precedes Alzheimer’s disease (AD) and is characterized by the loss of entorhinal neurons leading to a hippocampal disconnection. However, MCI patients also revert to normal cognition, suggest...

APOE -Sensitive Cholinergic Sprouting Compensates for Hippocampal Dysfunctions Due to Reduced Entorhinal Input

Archive ouverte | Bott, Jean-Bastien | CCSD

International audience. Brain mechanisms compensating for cerebral lesions may mitigate the progression of chronic neurodegenerative disorders such as Alzheimer's disease (AD). Mild cognitive impairment (MCI), which...

Differential contribution of APP metabolites to early cognitive deficits in a TgCRND8 mouse model of Alzheimer’s disease

Archive ouverte | Hamm, Valentine | CCSD

International audience. Alzheimer's disease (AD) is a neurodegenerative pathology commonly characterized by a progressive and irreversible deterioration of cognitive functions, especially memory. Although the etiolo...

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