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Involvement of G-quadruplex regions in mammalian replication origin activity

Archive ouverte | Prorok, Paulina | CCSD

International audience. Genome-wide studies of DNA replication origins revealed that origins preferentially associate with an Origin G-rich Repeated Element (OGRE), potentially forming G-quadruplexes (G4). Here, we ...

Human ORC/MCM density is low in active genes and correlates with replication time but does not solely define replication initiation zones

Archive ouverte | Kirstein, Nina | CCSD

Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with gene expression, repli...

Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

Archive ouverte | Kirstein, Nina | CCSD

International audience. Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm...

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