Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk

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Johansson, Annelie | Palli, Domenico | Masala, Giovanna | Grioni, Sara | Agnoli, Claudia | Tumino, Rosario | Giurdanella, Maria Concetta | Fasanelli, Francesca | Sacerdote, Carlotta | Panico, Salvatore | Mattiello, Amalia | Polidoro, Silvia | Jones, Michael | Schoemaker, Minouk, J | Orr, Nick | Tomczyk, Katarzyna | Johnson, Nichola | Fletcher, Olivia | Perduca, Vittorio | Baglietto, Laura | Dugué, Pierre-Antoine | Southey, Melissa | Giles, Graham, G | English, Dallas, R | Milne, Roger, L | Severi, Gianluca | Ambatipudi, Srikant | Cuenin, Cyrille | Chajes, Veronique | Romieu, Isabelle | Herceg, Zdenko | Swerdlow, Anthony | Vineis, Paolo | Flanagan, James

Edité par CCSD ; BioMed Central -

International audience. It is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesized that a woman's total lifetime estrogen exposure accumulates changes in DNA methylation, detectable in the blood, which could be used in risk assessment for breast cancer.

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