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Synthesis, kinase inhibition and anti-leukemic activities of diversely substituted indolopyrazolocarbazoles

Archive ouverte | Frazier, Théo | CCSD

International audience. Pyrazole analogues of the staurosporine aglycone K252c, in which the lactam ring was replaced by a pyrazole moiety, were synthesized. In this series, one or the other nitrogen atoms of the in...

Synthesis of new pyrazolo[4,3-a]phenanthridine Pim-1 inhibitors and evaluation of their cytotoxic activity towards the MOLM-13 acute myeloid leukemia cell line

Archive ouverte | Auvert, Etienne | CCSD

International audience. We synthesized new analogues of the anti-AML agent VS-II-173. We studied the effect of the substitution at the 1-and 5-positions of the pyrazolo[4,3-a]phenanthridine scaffold on Pim-1 kinase ...

Liposomes loaded with daunorubicin and an emetine prodrug for improved selective cytotoxicity towards acute myeloid leukaemia cells

Archive ouverte | Reiten, Ingeborg Nerbø | CCSD

International audience

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