Late side-effects after curative intent radiotherapy: Identification of hypersensitive patients for personalized strategy

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Bourgier, Céline | Lacombe, Jérôme | Solassol, Jérôme | Mangé, Alain | Pèlegrin, André | Ozsahin, Mahmut | Azria, David

Edité par CCSD ; Elsevier -

International audience. Radiation therapy undeniably enhances local control and thus improves overall survival in cancer patients. However, some long-term cancer survivors (less than 10%) develop severe late radio-induced toxicities altering their quality of life. Therefore, there is a need to identify patients who are sensitive to those toxicities and who could benefit from adapted care. In this review, we address all available techniques aiming to detect patients' hyper-radiosensitivity and present the scientific rationales these techniques are based on.

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