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Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilization

Archive ouverte | Chalbi, Myriam | CCSD

International audience. Little is known about the molecular mechanisms that induce gamete fusion during mammalian fertilization. After initial contact, adhesion between gametes only leads to fusion in the presence o...

Key roles of the zona pellucida and perivitelline space in promoting gamete fusion and fast block to polyspermy inferred from the choreography of spermatozoa in mice oocytes

Archive ouverte | Dubois, Yaëlle | CCSD

Abstract Mammalian fertilization is still lacking a comprehensive understanding of gamete fusion and block to polyspermy mechanisms. One reason is that they are highly dynamic processes involving transient events that can only be ...

Snapshot of sequential SNARE assembling states between membranes shows that N-terminal transient assembly initializes fusion

Archive ouverte | Wang, Yong Jian | CCSD

International audience. Many prominent biological processes are driven by protein assembling between membranes. Understanding the mechanisms then entails determining the assembling pathway of the involved proteins. ...

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