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Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis

Archive ouverte | Zhang, Qing | CCSD

International audience. Background The protein kinase mechanistic target of rapamycin (mTOR) controls cellular growth and metabolism. Although balanced mTOR signalling is required for proper muscle homeostasis, part...

LSD1 Controls Timely MyoD Expression via MyoD Core Enhancer Transcription

Archive ouverte | Scionti, Isabella | CCSD

International audience. MyoD is a master regulator of myogenesis. Chromatin modifications required to trigger MyoD expression are still poorly described. Here, we demonstrate that the histone demethylase LSD1/KDM1a ...

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

Archive ouverte | Risson, Valérie | CCSD

International audience

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