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Brain virtual histology with X-ray phase-contrast tomography Part II: 3D morphologies of amyloid-β plaques in Alzheimer’s disease models

Archive ouverte | Chourrout, Matthieu | CCSD

International audience. While numerous transgenic mouse strains have been produced to model the formation of amyloid-β (Aβ) plaques in the brain, effi cient methods for whole-brain 3D analysis of Aβ deposits have to...

Virtual histology of animal and human brains with Alzheimer's disease

Archive ouverte | Chauveau, Fabien | CCSD

International audience. Introduction Synchrotron Radiation X-ray Phase Computed Tomography (SR-PCT) of brain tissue can reveal different image contrast depending on sample preparation. Indeed, we have shown that eth...

High throughput three-dimensional imaging of myelin fibers in the whole mouse brain

Archive ouverte | Rositi, Hugo | CCSD

International audience. IntroductionInjury to the white matter (WM) leads to severe functional loss in many neurological diseases such as stroke and multiple sclerosis. In-vivo neuroimaging techniques such as diffus...

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