Afficher la couverture 'Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis. | Pascalis, Hervé' en grand format
/5

0 avis

Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis.

Archive ouverte

Pascalis, Hervé | Pascalis, Pascal | Lavergne, Anne | Bourreau, Eliane | Prévot-Linguet, Ghislaine | Kariminia, Amina | Pradinaud, Roger | Rafati, Sima | Launois, Pascal

Edité par CCSD ; American Society for Microbiology -

International audience. The cysteine proteinases CPA and CPB from Leishmania major induced Th1 responses in patients with leishmaniasis due to Leishmania guyanensis. Furthermore, cysteine proteinases induced neither interleukin 4 (IL-4) nor IL-13 and low levels of IL-10 in controls and patients. The results suggest that CPs would be quite good candidates for a vaccine against different Leishmania species.

Consulter en ligne

Suggestions

Du même auteur

Th2 responses predominate during the early phases of infection in patients with localized cutaneous leishmaniasis and precede the development of Th1 responses.

Archive ouverte | Pascalis, Hervé | CCSD

International audience. Intralesional Th2 responses preceded the development of Th1 responses in localized cutaneous leishmaniasis due to Leishmania guyanensis. Although the number of parasites increased in Th2 lesi...

LACK-Specific CD4 + T Cells That Induce Gamma Interferon Production in Patients with Localized Cutaneous Leishmaniasis during an Early Stage of Infection

Archive ouverte | Bourreau, Eliane | CCSD

International audience. ABSTRACT The profile of cytokines induced by soluble leishmania antigen (SLA) and the Leishmania homologue of the mammalian receptor for activated C kinase (LACK), a candidate vaccine against...

Interleukin (IL)–13 Is the Predominant Th2 Cytokine in Localized Cutaneous Leishmaniasis Lesions and Renders Specific CD4 + T Cells Unresponsive to IL‐12

Archive ouverte | Bourreau, Eliane | CCSD

International audience. Semiquantitative reverse transcription-polymerase chain reaction analysis of leishmania lesion cytokine profile showed a Th2 cytokine expression pattern, as reflected by interleukin (IL)-4 an...

Chargement des enrichissements...