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RANKL Treatment Releases the Negative Regulation of the Poly(ADP-Ribose) Polymerase-1 on Tcirg1 Gene Expression During Osteoclastogenesis

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Beranger, Guillaume, E. | Momier, David | Rochet, Nathalie | Quincey, Danielle | Guigonis, Jean-Marie | Samson, Michel | Carle, Georges, F. | Scimeca, Jean-Claude

Edité par CCSD ; American Society for Bone and Mineral Research -

International audience. The Tcirg1 gene encodes the osteoclast-specific a3 isoform of the V-ATPase a subunit. Using the mouse osteoclastic model RAW264.7 cells, we studied Tcirg1 gene expression, and we identified PARP-1 as a transcriptional repressor negatively regulated by RANKL during osteoclastogenesis.

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RANKL Treatment Releases the Negative Regulation of the Poly(ADP-Ribose) Polymerase-1 on Tcirg1 Gene Expression During Osteoclastogenesis.

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