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Mechanical heterogeneity favors fragmentation of strained actin filaments

Archive ouverte | de La Cruz, Enrique M. | CCSD

International audience. We present a general model of actin filament deformation and fragmentation in response to compressive forces. The elastic free energy density along filaments is determined by their shape and ...

Cofilin increases the bending flexibility of actin filaments: implications for severing and cell mechanics.

Archive ouverte | Mccullough, Brannon, R. | CCSD

International audience. We determined the flexural (bending) rigidities of actin and cofilactin filaments from a cosine correlation function analysis of their thermally driven, two-dimensional fluctuations in shape....

Origin of twist-bend coupling in actin filaments.

Archive ouverte | de La Cruz, Enrique M | CCSD

International audience. Actin filaments are semiflexible polymers that display large-scale conformational twisting and bending motions. Modulation of filament bending and twisting dynamics has been linked to regulat...

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