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WT1 Maintains Adrenal-Gonadal Primordium Identity and Marks a Population of AGP-like Progenitors within the Adrenal Gland.

Archive ouverte | Bandiera, Roberto | CCSD

International audience. Adrenal glands and gonads share a common primordium (AGP), but the molecular events driving differentiation are poorly understood. Here we demonstrate that the Wilms tumor suppressor WT1 is a...

WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.

Archive ouverte | Motamedi, Fariba Jian | CCSD

International audience. Kidney organogenesis requires the tight control of proliferation, differentiation and apoptosis of renal progenitor cells. How the balance between these cellular decisions is achieved remains...

Analysis of the Role of Igf2 in Adrenal Tumour Development in Transgenic Mouse Models

Archive ouverte | Drelon, Coralie | CCSD

International audience. Adrenal cortical carcinomas (ACC) are rare but aggressive tumours associated with poor prognosis. The two most frequent alterations in ACC in patients are overexpression of the growth factor ...

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