Syracuse

Lower Pregnancy Rates After IVF in Women Working as Occupational Cleaners A Preliminary Longitudinal Study

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Soen, Sabrina | Perrin, Jeanne | Sari-Minodier, Irène | Jouve, Elisabeth | Gnisci, Audrey | Courbiere, Blandine

Edité par CCSD ; Journal of Reproductive Medicine -

International audience. OBJECTIVE: To assess clinical, biological, and environ­ mental factors influencing pregnancy rates (PRs) after in vitro fertilization (IVF), and to study the influence of occupational, lifestyle, and domestic exposure on PR.STUDY DESIGN: A longi­ tudinal cohort study was performed in women who started an IVF cycle with a self­administered question­ naire concerning their envi­ ronmental and occupation­ al exposure. Medical data were obtained from medical files.RESULTS: Among 534 cycles, we showed a variety of factors that had an impact on PR: age, infertility du­ ration, number of mature oocytes and embryos. After multivariate analysis, women with "elementary" occu­ pations had a significantly lower PR (OR 5.6; 95% CI 1.3-23.7). Among them, 82% were cleaners.CONCLUSION: This preliminary result leads us to focus on a socio­professional category that is already rec­ ognized in the literature as at risk for congenital abnor­ malities during pregnancy. Further cohort studies are needed to study the influence of socio­professional cate­ gory on PR.

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