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FoxO3a overexpression prevents both glycogen overload and autophagic buildup in skeletal muscle of Pompe disease

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Pichon, Julien | Lagalice, Lydie | Deniaud, Johan | Babarit, Candice | Maurier, Virginie | Dubreil, Laurence | Larcher, Thibaut | Ayuso, Eduard | Ciron, Carine | Rouger, Karl | Colle, Marie-Anne

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FoxO3a overexpression prevents both glycogen overload and autophagic buildup in skeletal muscle of Pompe disease. 6eme congrès international de Myologie

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FoxO3a overexpression prevents both glycogen overload and autophagic buildup in skeletal muscle of Pompe disease.

Archive ouverte | Pichon, Julien | CCSD

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La surexpression de FoxO3a prévient la surcharge en glycogène et la dérégulation du flux autophagique dans le muscle squelettique dans la maladie de Pompe.

Archive ouverte | Pichon, Julien | CCSD

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FoxO3a overexpression prevents both glycogen overload and autophagic buildup in Pompe disease

Archive ouverte | Pichon, Julien | CCSD

Pompe disease (glycogen storage disease type II) is a lysosomal storage disorder caused by the mutation of acid α-glucosidase (Gaa), the unique enzyme degrading glycogen in glucose into lysosomes. A massive glycogen overload is de...

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