Influence of renal function estimation on pharmacokinetic modeling of vancomycin in elderly patients

Archive ouverte | Glatard, A. | CCSD

International audience. Vancomycin is a renally excreted drug, and its body clearance correlates with creatinine clearance. However, the renal function estimation equation that best predicts vancomycin clearance has...

Population modeling and simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of isoniazid in lungs

Archive ouverte | Lalande, Laure | CCSD

International audience. Among first-line antituberculosis drugs, isoniazid (INH) displays the greatest early bactericidal activity (EBA) and is key to reducing contagiousness in treated patients. The pulmonary pharm...

Population Modeling and Monte Carlo Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Rifampin in Lungs

Archive ouverte | Goutelle, Sylvain | CCSD