Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study
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Balazard, F. | Le Fur, S. | Valtat, S. | Valleron, A. | Thevenieau, Dominique | Chatel, Corinne Fourmy | Desailloud, Rachel | Bony-Trifunovic, Hélène | Ducluzeau, Pierre-Henri | Coutant, Régis | Caudrelier, Sophie | Pambou, Armelle | Dubosclard, Emmanuelle | Joubert, Florence | Jan, Philippe | Marcoux, Estelle | Bertrand, Anne-Marie | Mignot, Brigitte | Penformis, Alfred | Stuckens, Chantal | Piquemal, Régis | Barat, Pascal | Rigalleau, Vincent | Stheneur, Chantal | Fournier, Sylviane | Kerlan, Véronique | Metz, Chantal | Fargeot-Espaliat, Anne | Reznic, Yves | Olivier, Frédérique | Gueorguieva, Iva | Monier, Arnaud | Radet, Catherine | Gajdos, Vincent | Terral, Daniel | Vervel, Christine | Bendifallah, Djamel | Signor, Candace Ben | Dervaux, Daniel | Benmahammed, Abdelkader | Loeuille, Guy-André | Popelard, Françoise | Guillou, Agnès | Benhamou, Yves | Khoury, Jamil | Brossier, Jean-Pierre | Bassil, Joachim | Clavel, Sylvaine | Le Luyer, Bernard | Bougnères, Pierre | Labay, Françoise | Guemas, Isabelle | Weill, Jacques | Cappoen, Jean-Pierre | Nadalon, Sylvie | Lienhardt-Roussie, Anne | Paoli, Anne | Kerouedan, Claudie | Yollin, Edwige | Nicolino, Marc | Simonin, Gilbert | Cohen, Jacques | Atlan, Catherine | Tamboura, Agnès | Dubourg, Hervé | Pignol, Marie-Laure | Talon, Philippe | Jellimann, Stéphanie | Chaillous, Lucy | Baron, Sabine | Bortoluzzi, Marie-Noëlle | Baechler, Elisabeth | Salet, Randa | Zelinsky-Gurung, Ariane | Dallavale, Fabienne | Larger, Etienne | Laloi-Michelin, Marie | Gautier, Jean-François | Guérin, Bénédicte | Oilleau, Laure | Pantalone, Laetitia | Lukas, Céline | Guilhem, Isabelle | de Kerdanet, Marc | Wielickzo, Marie | Priou-Guesdon, Mélanie | Richard, Odile | Kurtz, François | Laisney, Norbert | Ancelle, Déborah | Guilhem, Guilhem | Boniface, Catherine | Bockel, Dominique | Dufillot, Denis | Razafimahefa, Berthe | Gourdy, Pierre | Lecomte, Pierre, B.A. | Pepin-Donat, Myriam | Combes-Moukhovsky, Emmanuelle | Zymmermann, Brigitte | Raoulx, Marina | Dumont, Anne
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CCSD ; BioMed Central -
International audience.
Background : The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedlybecause of changing environmental factors, which are yet largely unknown. The purpose of the study was tounravel environmental markers associated with T1D. Methods : Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends ofthe patients. Parents were asked to fill a 845-item questionnaire investigating the child’s environment before diagnosis.The analysis took into account the matching between cases and controls. A second analysis used propensity scoremethods. Results : We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnutcocoa spread consumption, wasp and bee stings with T1D, consumption of vegetables from a farm and death of a petby old age. Conclusions : The found statistical association of new environmental markers with T1D calls for replication in othercohorts and investigation of new environmental areas.
