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Genotype 1 hepatitis C virus envelope features that determine antiviral response assessed through optimal covariance networks

Archive ouverte | Murray, John | CCSD

International audience. The poor response to the combined antiviral therapy of pegylated alfa-interferon and ribavarin for hepatitis C virus (HCV) infection may be linked to mutations in the viral envelope gene E1E2...

Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.

Archive ouverte | Fofana, Isabel | CCSD

International audience. BACKGROUND & AIMS: The development of vaccines and other strategies to prevent hepatitis C virus (HCV) infection is limited by rapid viral evasion. HCV entry is the first step of infection; t...

Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients.

Archive ouverte | Pastor, Rebecca | CCSD

International audience. Anti-hepatitis B virus (HBV) therapy leads to the emergence of mutant viral strains during the treatment of chronic hepatitis B with nucleos(t)ides analogues. The existence of HBV variants wi...

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