Huntingtin affinity for partners is not changed by polyglutamine length: aggregation itself triggers aberrant interactions

Archive ouverte | Davranche, Aurélien | CCSD

International audience. Huntington's disease (HD) is caused by the expansion mutation above a length threshold of a polyglutamine (polyQ) stretch in the huntingtin (Htt) protein. Mutant Htt (mHtt) pathogenicity is p...

Identification of Nonpeptide Oxytocin Receptor Ligands by Receptor-Ligand Fingerprint Similarity Search

Archive ouverte | Weill, Nathanael | CCSD

A general framework to characterize inhibitors of calmodulin: use of calmodulin inhibitors to study the interaction between calmodulin and its calmodulin binding domains

Archive ouverte | Audran, Emilie | CCSD

International audience. The prominent role of Ca(2+) in cell physiology is mediated by a whole set of proteins involved in Ca(2+)-signal generation, deciphering and arrest. Among these intracellular proteins, calmod...