Endozepines

Archive ouverte

Tonon, Marie-Christine | Leprince, Jérôme | Morin, Fabrice | Gandolfo, Pierrick | Compère, Vincent | Pelletier, Georges | Malagón, María M. | Vaudry, Hubert

Edité par CCSD ; Elsevier -

International audience. The existence of specific binding sites for benzodiazepines has led to the discovery of endogenous ligands for benzodiazepine recep-tors that are collectively designated by the term endozepines. In the brain and in peripheral nervous tissues, endozepines are exclusively expressed by glial cells. The release of endozepines from cultured astrocytes is finely regulated by neurotransmitters and neuro-peptides. Endozepines exert their effects either through classical central- and peripheral-type benzodiazepine receptors or through G protein-coupled receptors. Intracerebroventricular injection of endozepines induces marked effects on anxiety, sleep, and food consumption. The concentration of endozepines in the brain and cerebrospinal fluid is affected in various diseases including depres-sion, Alzheimer’s disease, and hepatic encephalopathy.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion