Tracking Cancer Cells with Microfluidic High Frequency DEP Cytometer Implemented on BiCMOS Lab-on-Chip Platform

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Manczak, Rémi | Hjeij, Fatima | Provent, Thomas | Saada, Sofiane | Dalmay, Claire | Bessette, Barbara | Bégaud, Gaëlle | Battu, Serge | Blondy, Pierre | Jauberteau, Marie-Odile | Lalloué, Fabrice | Inac, Mesut | Baristiran Kaynak, Canan | Kaynak, Mehmet | Palego, Cristiano | Pothier, Arnaud

Edité par CCSD -

International audience. In this paper, a fully BiCMOS integrated microfluidic cell sorting platform for cell properties study is introduced. Operating in the radiofrequency range, the presented device combined Lab-on-Chip and IC technologies to achieve label free cytometry using in flow cell selective dielectrophoresis deviation. Taking benefit of CMOS stack and integration capability, the first prototypes demonstrate the ability to separate cells with different intracellular dielectric properties. These results pave the way to new innovative high throughput integrated IC solutions for detection of rare cells in the frame of cancer researches and treatment.

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