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Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies

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Neveu, Cindy | Dulin, Fabienne | Lefranc, Benjamin | Galas, Ludovic | Calbrix, Colas | Bureau, Ronan | Rault, Sylvain | Chuquet, Julien | Boutin, Jean A | Guilhaudis, Laure | Ségalas-Milazzo, Isabelle | Vaudry, David | Vaudry, Hubert | Sopkova-de Oliveira Santos, Jana | Leprince, Jérôme

Edité par CCSD ; Wiley -

International audience. The neuropeptide 26RFa and its cognate receptor GPR103 are involved in the control of food intake and bone mineralization. Here, we have tested, experimentally, the predicted ligand-receptor interactions by site-directed mutagenesis of GPR103 and designed point-substituted 26RFa analogues.

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