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High Dimensional Classification with combined Adaptive Sparse PLS and Logistic Regression

Archive ouverte | Durif, Ghislain | CCSD

International audience. Motivation: The high dimensionality of genomic data calls for the development of specific classification methodologies, especially to prevent over-optimistic predictions. This challenge can b...

Probabilistic Count Matrix Factorization for Single Cell Expression Data Analysis

Archive ouverte | Durif, Ghislain | CCSD

International audience. Motivation: The development of high throughput single-cell sequencing technologies now allows the investigation of the population diversity of cellular transcriptomes. The expression dynamics...

Divergent clonal differentiation trajectories establish CD8+ memory T cell heterogeneity during acute viral infections in humans

Archive ouverte | Mold, Jeff | CCSD

International audience. The CD8+ T cell response to an antigen is composed of many T cell clones with unique T cell receptors, together forming a heterogeneous repertoire of effector and memory cells. How individual...

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