Albumin infusion improves endothelial function in septic shock patients: a pilot study

Archive ouverte

Hariri, Geoffroy | Joffre, Jérémie | Deryckere, Stephanie | Bigé, Naïke | Dumas, Guillaume | Baudel, Jean-Luc | Maury, Eric | Guidet, Bertrand | Ait-Oufella, Hafid

Edité par CCSD ; Springer Verlag -

International audience. Sepsis is a life-threatening condition in response to microbe injury, leading to tissue hypoperfusion, multiorgan failure and death. Human and experimental studies have shown that endothelial dysfunction is involved in microcirculatory blood flow impairment through several mechanisms including vasomotor tone dysregulation, activation of coagulation and glycocalyx damage [1]. Experimental studies suggested that human serum albumin (HSA) could have protective effects on endothelial cells [2], but such a hypothesis has never been directly tested in vivo. The aim of this study was to compare the effect of saline versus HSA bolus infusion on endothelial function in septic shock patients.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion