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Configurational fluctuations and flavin-substrate interactions in the flavoenzyme ThyX studied by time- and spectrally resolved fluorescence

Archive ouverte | Laptenok, Sergey, P. | CCSD

International audience. Femtosecond-resolved fluorescence of bacterial thymidilate synthase using a Kerr-gate based setup identifies a close-by tyrosine involved in flavin fluorescence quenching, shows that the subs...

Ultrafast real-time visualization of active site flexibility of flavoenzyme thymidylate synthase ThyX.

Archive ouverte | Laptenok, Sergey, P. | CCSD

International audience. In many bacteria the flavoenzyme thymidylate synthase ThyX produces the DNA nucleotide deoxythymidine monophosphate from dUMP, using methylenetetrahydrofolate as carbon donor and NADPH as hyd...

Flavin-dependent thymidylate synthase X limits chromosomal DNA replication.

Archive ouverte | Escartin, Frédéric | CCSD

International audience. We have investigated the hitherto unexplored possibility that differences in the catalytic efficiencies of thymidylate synthases ThyX and ThyA, enzymes that produce the essential DNA precurso...

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