Origin of HTLV-1 in hunters of nonhuman primates in Central Africa

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Kazanji, Mirdad | Mouinga-Ondémé, Augustin | Lekana-Douki-Etenna, Sonia | Caron, Mélanie | Makuwa, Maria | Mahieux, Renaud | Gessain, Antoine

Edité par CCSD ; Oxford University Press -

International audience. Of 78 Gabonese individuals who had received bites from nonhuman primates (NHPs) while hunting, 7 were infected with human T lymphotropic virus (HTLV-1). Five had been bitten by gorillas and were infected with subtype B strains; however, a 12-year-old girl who was severely bitten by a Cercopithecus nictitans was infected with a subtype D strain that was closely related to the simian T lymphotropic virus (STLV-1) that infects this monkey species. Her mother was infected with a subtype B strain. These data confirm that hunters in Africa can be infected by HTLV-1 that is closely related to the strains circulating among local NHP game. Our findings strongly suggest that a severe bite represent a risk factor for STLV-1 acquisition.

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