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Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium.

Archive ouverte | Schlattner, Uwe | CCSD

International audience. Mitochondrial creatine kinase (MtCK) co-localizes with mitochondrial porin (voltage-dependent anion channel) and adenine nucleotide translocator in mitochondrial contact sites. A specific, di...

Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation.

Archive ouverte | Dolder, Max | CCSD

International audience. Mitochondria from transgenic mice, expressing enzymatically active mitochondrial creatine kinase in liver, were analyzed for opening of the permeability transition pore in the absence and pre...

Divergent enzyme kinetics and structural properties of the two human mitochondrial creatine kinase isoenzymes.

Archive ouverte | Schlattner, Uwe | CCSD

International audience. The mitochondrial isoenzymes of creatine kinase (MtCK), ubiquitous uMtCK and sarcomeric sMtCK, are key enzymes of oxidative cellular energy metabolism and play an important role in human heal...

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