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New synthesis ofcis 5-tert-butyl-L-proline via cuprate. Evaluation as acis proline mimetic in a biological active octapeptide

Archive ouverte | Aubry, Carine | CCSD

International audience. cis 5-tert-butyl-L-proline (Cbp) was prepared rapidly and efficiently by the addition of low-valent tert-butyl cuprate to an aminal derived from proline. [Cbp(2), D-Leu(5)]-OP was then synthe...

Synthèse et activité biologique d’analogues de l’octadécaneuropeptide (ODN), ligand endogène potentiel des récepteurs des benzodiazépines. Etudes des relations structure-activité.

Archive ouverte | Leprince, Jérôme | CCSD

International audience

Asymmetric synthesis of fluoropseudopeptides towards constrained prolines and analogue of neuropeptide 26 RFa

Archive ouverte | Couve-Bonnaire, Samuel | CCSD

International audience

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