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Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism.

Archive ouverte | Kappeler, Laurent | CCSD

International audience. Mutations that decrease insulin-like growth factor (IGF) and growth hormone signaling limit body size and prolong lifespan in mice. In vertebrates, these somatotropic hormones are controlled ...

Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin

Archive ouverte | Daniel de Magalhaes Filho, C. | CCSD

International audience. Insulin-like growth factors control numerous processes, namely somatic growth, metabolism and stress resistance, connecting this pathway to aging and age-related diseases. Insulin-like growth...

Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin

Archive ouverte | de Magalhaes Filho, C Daniel | CCSD

International audience

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