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Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

Archive ouverte | Kanneganti, Thirumala-Devi | CCSD

International audience. Viral infection induces the production of interleukin (IL)-1beta and IL-18 in macrophages through the activation of caspase-1, but the mechanism by which host cells sense viruses to induce ca...

RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs.

Archive ouverte | Park, Jong-Hwan | CCSD

International audience. RICK is a kinase that has been implicated in Nod1 and Nod2 signaling. In addition, RICK has been proposed to mediate TLR signaling in that its absence confers reduced responses to certain bac...

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

Archive ouverte | Kanneganti, Thirumala-Devi | CCSD

International audience

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