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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

Archive ouverte | Kanneganti, Thirumala-Devi | CCSD

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Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes.

Archive ouverte | Ozören, Nesrin | CCSD

International audience. Apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC) is an adaptor molecule that has recently been implicated in the activation of caspase-1. We ha...

Galactosaminogalactan activates the inflammasome to provide host protection

Archive ouverte | Briard, Benoit | CCSD

International audience. Galactosaminogalactan of Aspergillus fumigatus acts as a pathogen-associated molecular pattern that activates the NLRP3 inflammasome, which is crucial for anti-fungal host defence.Inflammasom...

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