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Mitochondrial Nm23-H4/NDPK-D is Multifunctional: Intermembrane Cardiolipin Transfer Linked to Apoptosis

Archive ouverte | Schlattner, Uwe | CCSD

International audience. Nm23-H4/NDPK-D forms symmetrical homohexameric complexes in the mitochondrial intermembrane space. The well established function of the enzyme is phosphotransfer activity as a nucleoside diph...

Externalization of Cardiolipin as an “Eat-Me” Mitophageal Signal is Facilitated by NDPK-D

Archive ouverte | Huang, Zhentai | CCSD

International audience. Mitochondria are vulnerable to damage, particularly by oxidative stress-induced injury imposed by many genetic and environmental factors. These malfunctioning mitochondria have to be eliminat...

Mitochondrial NM23-H4/NDPK-D: a bifunctional nanoswitch for bioenergetics and lipid signaling

Archive ouverte | Schlattner, Uwe | CCSD

International audience. A novel paradigm for the function of the mitochondrial nucleoside diphosphate kinase NM23-H4/NDPK-D is proposed: acting as a bifunctional nanoswitch in bioenergetics and cardiolipin (CL) traf...

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