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Fetal skin fibroblasts: A cell model for studying the retinoid pathway in congenital diaphragmatic hernia

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Goumy, Carole | Coste, Karen | Marceau, Geoffroy | Gouas, Laetitia | Tchirkov, Andrei | Vago, Philippe | Gallot, Denis | Sapin, Vincent | Tchirkov, Andreã¯

Edité par CCSD ; Wiley -

International audience. Although there is strong evidence that genetic factors play a pathogenic role in congenital diaphragmatic hernia (CDH), few causal genes have been identified in humans. A number of studies, essentially in animal models, have suggested that disruption of the retinoid signaling pathway plays a major role in the pathogenesis of CDH. Our hypothesis is that human fetal skin fibroblasts express some metabolic and molecular actors of the retinoid pathway and that they offer convenient cellular material for investigating the molecular retinoid pathway defects associated with CDH.

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