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On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

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Medve, Laura | Achilli, Silvia | Serna, Sonia | Zuccotto, Fabio | Varga, Norbert | Thépaut, Michel | Civera, Monica | Vivès, Corinne | Fieschi, Franck | Reichardt, Niels | Bernardi, Anna

Edité par CCSD ; Wiley-VCH Verlag -

International audience. A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin, and dectin-2. Glycomimetic ligands able to interact with dectin-2 were identified for the first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed.

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