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Pressure support ventilation + sigh in acute hypoxemic respiratory failure patients: study protocol for a pilot randomized controlled trial, the PROTECTION trial

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Mauri, Tommaso | Foti, Giuseppe | Fornari, Carla | Constantin, Jean-Michel | Guérin, Claude | Pelosi, Paolo | Ranieri, Marco | Conti, Sara | Tubiolo, Daniela | Rondelli, Egle | Lovisari, Federica | Fossali, Tommaso | Spadaro, Savino | Grieco, Domenico, Luca | Navalesi, Paolo | Calamai, Italo | Becher, Tobias | Roca, Oriol | Wang, Yu-Mei | Knafelj, Rihard | Cortegiani, Andrea | Mancebo, Jordi | Brochard, Laurent, J. | Pesenti, Antonio

Edité par CCSD ; BioMed Central -

International audience. Background: Adding cyclic short sustained inflations (sigh) to assisted ventilation yields optimizes lung recruitment, decreases heterogeneity and reduces inspiratory effort in patients with acute hypoxemic respiratory failure (AHRF). These findings suggest that adding sigh to pressure support ventilation (PSV) might decrease the risk of lung injury, shorten weaning and improve clinical outcomes. Thus, we conceived a pilot trial to test the feasibility of adding sigh to PSV (the PROTECTION study).

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