The “computable egg”: Myth or useful concept?

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The “computable egg”: Myth or useful concept?

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Biasuz, Kilian | Leggio, Bruno | Faure, Emmanuel | Lemaire, Patrick

International audience. In 1994, Lewis Wolpert wondered “Will the egg be computable? That is given a total description of the fertilized egg – the total DNA sequence and the location of all proteins and RNA – could one predict how the embryo will develop?”. In this review, we discuss what computing the embryo entails and explore how advanced imaging, single-cell genomics and physical measurements are changing our view of the embryo and enable the development of multi-scale computational models that are starting to explain in physical terms how the genome controls the dynamic behavior of each cell in a developing embryo.

Langue: en

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