Afficher la couverture 'Monitoring NK cell activity in patients with hematological malignancies | Viel, Sébastien' en grand format
/5

0 avis

Monitoring NK cell activity in patients with hematological malignancies

Archive ouverte

Viel, Sébastien | Charrier, Emily | Marçais, Antoine | Rouzaire, Paul | Bienvenu, Jacques | Karlin, Lionel | Salles, Gilles | Walzer, Thierry

Edité par CCSD ; Taylor & Francis -

International audience. Natural killer (NK) cells are lymphocytes of the innate immune system that can recognize and kill various types of malignant cells. Monitoring the activity of peripheral NK cells in patients affected by hematological malignancies may provide prognostic information or unveil ongoing tumor-specific immune responses. Moreover, further insights into the biology of NK cells might also promote the development of novel strategies for stimulating their anticancer activity. Here, we review the main methods to monitor phenotypic and functional NK cell properties in cancer patients, focusing on individuals affected by multiple myeloma, a hematological malignancy currently treated with immunomodulatory drugs.

Consulter en ligne

Suggestions

Du même auteur

One-Year Follow-Up of Natural Killer Cell Activity in Multiple Myeloma Patients Treated With Adjuvant Lenalidomide Therapy

Archive ouverte | Besson, Laurie | CCSD

International audience. Multiple myeloma (MM) is a proliferation of tumoral plasma B cells that is still incurable. Natural killer (NK) cells can recognize and kill MM cells in vitro and can limit MM growth in vivo....

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

Archive ouverte | Viel, Sébastien | CCSD

International audience. Transforming growth factor-beta (TGF-beta) is a major immunosuppressive cytokine that maintains immune homeostasis and prevents autoimmunity through its antiproliferative and anti-inflammator...

Alteration of Natural Killer cell phenotype and function in obese individuals

Archive ouverte | Viel, Sébastien | CCSD

International audience. Obesity is associated with increased cancer rates and higher susceptibility to infections. The adipose tissue of obese individuals is inflammatory and may negatively impact on innate and adap...

Chargement des enrichissements...