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Methicillin-susceptible Staphylococcus aureus clonal complex 398: high prevalence and geographical heterogeneity in bone and joint infection and nasal carriage

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Valour, Florent | Tasse, Jason | Trouillet-Assant, Sophie | Rasigade, Jean-Philippe | Lamy, B. | Chanard, E. | Verhoeven, P. | Decousser, J.-W. | Marchandin, H. | Bès, Michèle | Chidiac, Christian | Vandenesch, François | Ferry, Tristan | Laurent, Frédéric | Lyon Bone And Joint Infection Study Group, On Behalf of The

Edité par CCSD ; Elsevier for the European Society of Clinical Microbiology and Infectious Diseases -

International audience. The prevalence of clonal complex (CC) 398 methicillin-susceptible Staphylococcus aureus (MSSA) was unexpectedly high among bone and joint infections (BJIs) and nasal-colonizing isolates in France, with surprising geographical heterogeneity. With none of the major, most-known staphylococcal virulence genes, MSSA CC398 BJI was associated with lower biological inflammatory syndrome and lower treatment failure rates.

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