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Tocilizumab in the treatment of mixed connective tissue disease and overlap syndrome in children

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Cabrera, Natalia | Duquesne, Agnes | Desjonquères, Marine | Larbre, Jean-Paul | Lega, Jean-Christophe | Fabien, Nicole | Belot, Alexandre

Edité par CCSD ; BMJ -

International audience. Arthritis is one of the main manifestations of mixed connective tissue disease (MCTD) and overlap syndrome in children and can be responsible for functional disability. We report on 2 children with arthritis that were dramatically improved by a treatment with interleukin-6 (IL-6) blockers in the context of connective tissue disease. However, in both cases, other systemic autoimmune symptoms were not modified by the treatment and autoantibodies tend to increase, suggesting a differential effect of IL-6 inhibition on articular inflammation and systemic autoimmunity.

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