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In-situ and ex-situ rheometry of high density Yarrowia lipolytica broth: determination of critical concentration and impact of yeast-mycelial transition

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Kraiem, Hazar | Manon, Yannick | Anne-Archard, Dominique | Fillaudeau, Luc

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The specificity of microbial bioreactions which give rise to irreducible couplings with hydrodynamics and heat and mass transfers, led into complex (three phases medium) and dynamic (auto-biocatalytic reaction) systems. Cells (concentration, shape, dimension, physiology…) strongly affect physico-chemical properties of broth and the modification of these characteristics interacts with bioprocess performances (specific rates, yields…) with an improvement or, more generally, a decrease of yields.

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