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Characterization of the mechanisms controlling Greatwall activity.

Archive ouverte | Vigneron, Suzanne | CCSD

International audience. Here we investigate the mechanisms regulating Greatwall (Gwl), a serine/threonine kinase essential for promoting the correct timing of mitosis. We identify Gwl as a unique AGC kinase that, un...

The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A.

Archive ouverte | Gharbi-Ayachi, Aicha | CCSD

International audience. Initiation and maintenance of mitosis require the activation of protein kinase cyclin B-Cdc2 and the inhibition of protein phosphatase 2A (PP2A), which, respectively, phosphorylate and dephos...

Greatwall, a new guardian of mitosis. Greatwall, un nouveau gardien de la mitose

Archive ouverte | Gharbi-Ayachi, Aicha | CCSD

International audience

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