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Characterization of the typical multidrug resistance profile in human uveal melanoma cell lines and in mouse liver metastasis derivatives.

Archive ouverte | Labialle, Stéphane | CCSD

International audience. Uveal melanoma is the most common intraocular malignancy. To study its biology, stable cell lines provide a useful tool, but these are very difficult to obtain. A stable and rapidly growing h...

Major cytogenetic aberrations and typical multidrug resistance phenotype of uveal melanoma: Current views and new therapeutic prospects

Archive ouverte | Labialle, Stéphane | CCSD

International audience. Uveal melanoma is the most frequent intra-ocular cancer. The recent development of new chromosome-related technologies have permitted the elucidation of both the cytogenetics and the natural ...

New invMED1 element cis-activates human multidrug-related MDR1 and MVP genes, involving the LRP130 protein

Archive ouverte | Labialle, Stéphane | CCSD

International audience. The MDR1 gene is a key component of the cytotoxic defense network and its overexpression results in the multidrug resistance (MDR) phenotype. However, the molecular mechanisms that regulate t...

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