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Two sides of the same coin: NEO-PUFAs in Rett syndrome and post-infarction cardiac arrhythmias

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Demion, Marie | Oger, Camille | Vigor, Claire | Thireau, Jérôme | Le Guennec, Jean-Yves | Durand, Thierry | Galano, Jean-Marie | Lee, Jetty Chung-Yung

Edité par CCSD ; Wiley-VCH Verlag [2000-....] -

International audience. An imbalance between oxidants and antioxidants that favors the oxidants leads to a disruption of the redox signaling control and/or molecular damage. The action of the oxidants in a non‐enzymatic process generates isoprostanoids from polyunsaturated fatty acids. In this review, we will focus on the effects of ω3‐polyunsaturated fatty acids in two different pathogeneses related to chronic and acute oxidative stress, one in neurodevelopmental, also known as the Rett syndrome, and the second in myocardial infarction and cardiac arrhythmias, respectively. We hypothesize that ω3‐polyunsaturated fatty acid supplementation displays antioxidant properties under a high oxidative stress situation, as in the Rett Syndrome, as well as protective properties of isoprostanoids from polyunsaturated fatty acids in pro‐arrhythmic conditions.

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