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CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts.

Archive ouverte | Saint-Paul, Laetitia | CCSD

IF 5.008. International audience. CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. Exploiting CD45 KO mice and lentiviral shRNA, ...

Symplekin, a polyadenylation factor, prevents MOZ and MLL activity on HOXA9 in hematopoietic cells

Archive ouverte | Largeot, Anne | CCSD

International audience. MOZ and MLL encoding a histone acetyltransferase and a histone methyltransferase, respectively, are targets for recurrent chromosomal translocations found in acute myeloblastic or lymphoblast...

Trim33/Tif1γ is involved in late stages of granulomonopoiesis in mice.

Archive ouverte | Chrétien, Marie-Lorraine | CCSD

IF 2.303 . International audience. Trim33/Tif1γ (Trim33) is a member of the tripartite motif family. Using a conditional hematopoietic-specific Trim33 knock-out (Trim33(Δ/Δ)) mouse, we showed previously that Trim33 ...

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