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Cell-free and intracellular nucleic acids: new non-invasive biomarkers to explore male infertility

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Boissière, Anne | Gala, Anna | Ferrières-Hoa, Alice | Mullet, Tiffany | Baillet, Solenne | Petiton, Amaël | Torre, Antoine | Hamamah, Samir

Edité par CCSD ; BioMed Central -

International audience. Male infertility is a devastating problem that affects many couples worldwide. However, the molecular mechanisms and causes of idiopathic male infertility remain unclear. Circulating cell-free nucleic acids have an important role in human physiology and emerging evidence suggests that they play a role in male infertility. This review summarizes recent results on cell-free and intracellular nucleic acids in male infertility and discusses their potential use as biomarkers of male infertility in the clinical practice.

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